Author

Amanda L. Hughes

University of DundeeORCID 0000-0002-1976-6634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 2 Assay:ChIP-seq· 1 Research Focus:fine-mapping· 1 Assay:long-read sequencing· 1 Research Focus:protein structure prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

D. NormaniD· 2 shared Hassane El MkamiiD· 2 shared Ramasubramanian SundaramoorthyiD· 2 shared Tom Owen‐HughesiD· 2 shared Aaron N. BrooksiD· 1 shared Anavi Jalan· 1 shared Barbara TreutleiniD· 1 shared Bettina BöttcheriD· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

D. NormanORCID

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3 papers

Recent·Most cited

GenomicsCellPeer-reviewedNov 1, 2023

Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions

Yu Zhao, Camila Coelho, Amanda L. Hughes…·Jef D. Boeke

The paper uses CRISPR D-BUGS and chromosome swapping to identify and resolve genetic interactions in synthetic chromosomes, revealing unexpected links between transcription, inositol metabolism, and tRNA abundance.

117 citationstop 1%

whole-genome sequencinglong-read sequencing

𝕏 PostBluesky

Molecular BiologyeLifePeer-reviewedFeb 25, 2018

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

Ramasubramanian Sundaramoorthy, Amanda L. Hughes, Hassane El Mkami…·Tom Owen‐Hughes

The paper presents structures of yeast Chd1 bound to a ubiquitinylated nucleosome, revealing how it interacts with DNA and histone modifications.

103 citationstop 2%

yeastChIP-seq

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Molecular BiologyeLifePeer-reviewedMar 23, 2017

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes.

Ramasubramanian Sundaramoorthy, Amanda L. Hughes, Vijender Singh…·Tom Owen‐Hughes

This study models the structural changes in the Chd1 protein when bound to nucleosomes, revealing how ATP binding alters its conformation and DNA interactions.

62 citationstop 4%

yeastexperimental assay

𝕏 PostBluesky