Tom Owen‐Hughes

This study shows that transcription restart after DNA replication promotes chromatin reestablishment but is also linked to genotoxic stress.

The paper presents structures of yeast Chd1 bound to a ubiquitinylated nucleosome, revealing how it interacts with DNA and histone modifications.

This study identifies SINHCAF/FAM60A as a component of the SIN3A-HDAC complex that regulates the hypoxia response and shows its inverse correlation with HIF2 mRNA levels, predicting cancer patient survival.

This study models the structural changes in the Chd1 protein when bound to nucleosomes, revealing how ATP binding alters its conformation and DNA interactions.