Michael J. Rae

Analysis of the current state of frailty indexes and their implementation for aging intervention studies

This paper evaluates rodent frailty indexes and their implementation in aging studies, highlighting inconsistencies in frailty parameters and recommending standardized protocols.

The Old genetically heterogeneous Mouse Model Recapitulates Chronic and Persistent Idiopathic Pulmonary Fibrosis with Strong Senescence Signatures

This study develops an improved IPF mouse model using aged mice that better mimics the persistent disease features and senescence observed in humans.

Cell-Surface LAMP1 is a Senescence Marker in Aging and Idiopathic Pulmonary Fibrosis

The paper identifies LAMP1 as a cell-surface biomarker for senescent cells in aging and idiopathic pulmonary fibrosis and demonstrates its targeting using a dual antibody-drug conjugate.

γδ T Cells Target and Ablate Senescent Cells in Aging and Alleviate Pulmonary Fibrosis

This study shows γδ T cells eliminate senescent cells in aging and reduce pulmonary fibrosis by targeting senescent cells in mice and humans.

Inhibition of PIKfyve kinase induces senescent cell death by suppressing lysosomal exocytosis and leads to improved outcomes in a mouse model of idiopathic pulmonary fibrosis

The paper identifies apilimod as a senolytic drug that selectively kills senescent cells by inhibiting lysosomal exocytosis, showing therapeutic benefit in a mouse model of pulmonary fibrosis.