Molecular BiologybioRxivPreprint
Inhibition of PIKfyve kinase induces senescent cell death by suppressing lysosomal exocytosis and leads to improved outcomes in a mouse model of idiopathic pulmonary fibrosis
Anna Barkovskaya, Kristie Kim, Apoorva Shankar…·Amit Sharma
The paper identifies apilimod as a senolytic drug that selectively kills senescent cells by inhibiting lysosomal exocytosis, showing therapeutic benefit in a mouse model of pulmonary fibrosis.
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