Gabriel Meca-Laguna

This study develops an improved IPF mouse model using aged mice that better mimics the persistent disease features and senescence observed in humans.

The paper identifies LAMP1 as a cell-surface biomarker for senescent cells in aging and idiopathic pulmonary fibrosis and demonstrates its targeting using a dual antibody-drug conjugate.

This study shows γδ T cells eliminate senescent cells in aging and reduce pulmonary fibrosis by targeting senescent cells in mice and humans.

The paper identifies apilimod as a senolytic drug that selectively kills senescent cells by inhibiting lysosomal exocytosis, showing therapeutic benefit in a mouse model of pulmonary fibrosis.