Aaron M. Fleming

Single-molecule nanopore sequencing reveals spatial coordination of rRNA modifications in human ribosomes

This study uses single-molecule nanopore sequencing to analyze rRNA modifications in human cells, revealing local coordination of modifications and their response to drug treatment.

Nanopore sequencing reveals operon-specific ribosome remodeling accompanying naphthyridone resistance in Staphylococcus aureus

This study uses nanopore sequencing to identify operon-specific ribosome remodeling in Staphylococcus aureus resistant to naphthyridone antibiotics.

Ribosomal RNA tentacles are targets of free radical damage in mammalian cells during oxidative and inflammatory stress

This study maps oxidative and nitrosative damage to ribosomal RNA in human cells under stress, revealing distinct damage patterns in cytosolic and mitochondrial ribosomes.

CO2 protects cells from iron-Fenton oxidative DNA damage in E. coli and humans

The paper shows CO2 protects cells from iron-Fenton oxidative DNA damage by generating carbonate radical anion, leading to guanine oxidation in both E. coli and humans.

The Apurinic/Apyrimidinic Endodeoxyribonuclease 1 is an RNA G-quadruplex binding protein and regulates miR-92b expression in cancer cells

This study identifies APE1 as an RNA G-quadruplex binding protein that regulates miR-92b expression by modulating rG4 structure folding and miRNA maturation in cancer cells.