Erik Dassi

This study identifies RBMXL3 as a primate-specific RNA-binding protein that regulates RNA metabolism and suppresses LINE-1 retrotransposition in human spermatogenesis.

The paper investigates DDX53's role in human germ cells using TCam-2 cells, showing its involvement in RNA metabolism, splicing, and potential interactions with RNA molecules.

This study identifies METTL3-mediated m6A modification of DNMT1 as a driver of ovarian cancer progression by enhancing DNMT1 translation and suppressing tumor suppressors.

The paper shows RNA G-quadruplexes regulate mitochondrial function by modulating cytoplasmic mRNA translation of nuclear-encoded mitochondrial proteins, impacting energy metabolism and cancer cell proliferation.

This study shows that Fibrillarin regulates oncogenic protein pools and ribosomal composition in triple-negative breast cancer by modulating rRNA methylation and RPS28 levels.

This study identifies YTHDF paralogs and VIRMA as major tumor drivers among m6A core genes through a pan-cancer analysis of 10,000 samples.

This study identifies APE1 as an RNA G-quadruplex binding protein that regulates miR-92b expression by modulating rG4 structure folding and miRNA maturation in cancer cells.

This study shows that CHD8 suppression reduces H3K36me3 levels and alters alternative splicing of ~2000 genes, linking CHD8 to RNA processing and ASD.

The paper shows that CAG repeat expansion in Huntington's disease disrupts splicing, reducing circular RNA production and affecting neural progenitors and striatum before symptoms appear.

This paper shows DHX30 coordinates cytoplasmic and mitochondrial translation, affecting cancer cell survival and prognosis through a 15-gene signature.

The paper identifies dyskerin's role in regulating mRNA expression and nuclear hormone receptor dependence through snoRNA-retaining transcripts in breast cancer.

The paper introduces INSPEcT-, a computational method to infer RNA synthesis, processing, and degradation dynamics from total RNA data without metabolic labeling, and applies it to study post-transcriptional regulation in various conditions.

This study identifies a translational control mechanism regulated by PCBP2 and DHX30 that determines the outcome of p53 activation by Nutlin, shifting the response from cell cycle arrest to apoptosis.

The paper identifies two structural features of the RBP-RBP regulatory network: RBP clusters and RBP chains, which together enable coordinated control of gene expression.

This study shows polyglutamine-expanded androgen receptor disrupts muscle function by altering calcium dynamics and excitation-contraction coupling gene expression, which can be reversed by treatment.

The paper identifies 5HCEs in human 5UTRs, finds they are enriched in homeotic genes, and shows RBMX regulates these genes through post-transcriptional mechanisms.