Author

Ramu Vadukapuram

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexey KozlenkoviD· 2 shared Chunyu LiuiD· 2 shared Stella M. DrachevaiD· 2 shared Andrew J. DworkiD· 1 shared Andy Yang· 1 shared Annie W. ShiehiD· 1 shared Bingshan LiiD· 1 shared Chao CheniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersNeuroscience

Alexey KozlenkovORCID

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3 papers

Recent·Most cited

Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome

Heng Xu, Jo-fan Chien, Alexey Kozlenkov, Ramu Vadukapuram, Junhao Li, Yu Wei, Andrew J. Dwork, Chunyu Liu, Stella M. Dracheva, Eran A. Mukamel

The paper measures 5-methyl-cytosine and 5-hydroxymethyl-cytosine in human neurons across the lifespan, showing dynamic changes in hmC linked to transcription, chromatin state, and sex-specific gene regulation.

bioRxiv · Feb 19, 2026 · PreprintNeuroscience

The impact of common variants on gene expression in the human brain: from RNA to protein to schizophrenia risk

Qiuman Liang, Yi Jiang, Annie W. Shieh, Dan Zhou, Rui Chen, Feiran Wang, Meng Michelle Xu, Mingming Niu, Xusheng Wang, Dalila Pinto, Yue Wang, Lijun Cheng, Ramu Vadukapuram, Chunling Zhang, Kay S. Grennan, , Sidney H. Wang

The paper identifies eQTLs, rQTLs, and pQTLs in the human brain and shows that many eQTL effects are attenuated post-transcriptionally, yet still correlate with schizophrenia GWAS signals.

Nature Communications · Nov 28, 2025Peer-reviewedGenetics

Long-read transcriptomics of purified human cortical cell types exposes glial isoform complexity and disease-relevant transcript architecture

Andy Yang, Miguel Rodriguez, Alexey Kozlenkov, Ramu Vadukapuram, Yasmin Hurd, Stella M. Dracheva, Jack Humphrey, Michael S. Breen

The paper uses long-read transcriptomics to analyze human cortical cell types, revealing extensive isoform diversity in glial cells and identifying novel transcripts with disease-relevant splice variants.

bioRxiv · Nov 25, 2025 · PreprintNeuroscience