Bruno Kieffer

A hotspot for conformational heterogeneity driven by proline isomerisation in the androgen receptor disordered N-terminal domain

This study identifies a conserved proline-rich region in the androgen receptor N-terminal domain that shows conformational heterogeneity driven by cis proline conformers, modulated by phosphorylation and mutations.

Ultrahigh-throughput discovery of modified aptamers as specific and potent enzyme inhibitors

The paper introduces an ultrahigh-throughput strategy to discover modified aptamers as specific and potent enzyme inhibitors, demonstrating its effectiveness with an inhibitor of SPM-1.

Molecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer

This study identifies structural and biophysical details of the MED1-VDR-RXR interaction, revealing new insights into coactivator recognition by nuclear receptor complexes.