This study identifies primulagenin A as a potent inverse agonist of RORγ, showing efficacy in inhibiting Th17 cell differentiation and reducing IL-17A production.

Acta Pharmaceutica Sinica B · Mar 14, 2026Peer-reviewedPharmacology & Toxicology

New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands and transcriptional coregulators

Izabella Tambones, Amin Sagar, Pavla Vaňková, Dmitry S. Loginov, Coralie Carivenc, Natacha Rochel, William Bourguet, Petr Man, Pau Bernadó, Albane le Maire

This study reveals how DNA sequence and ligand binding influence the structural dynamics of RAR/RXR-coregulator complexes through integrative structural analysis.

Nucleic Acids Research · Sep 23, 2025Peer-reviewedBiochemistry

Molecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer

Anna Y. Belorusova, Maxime Bourguet, Steve Hessmann, Sandra Chalhoub, Bruno Kieffer, Sarah Cianférani, Natacha Rochel

This study identifies structural and biophysical details of the MED1-VDR-RXR interaction, revealing new insights into coactivator recognition by nuclear receptor complexes.

Nucleic Acids Research · Sep 8, 2020Peer-reviewedMolecular Biology

The tumor suppressor FBW7 and the vitamin D receptor are mutual cofactors.

Reyhaneh Salehi-Tabar, Babak Memari, Hilary Wong, Vassil Dimitrov, Natacha Rochel, John H. White

This study shows that the vitamin D receptor (VDR) and FBW7 are mutual cofactors that enhance each other's function, promoting cancer prevention through accelerated degradation of target proteins.

Molecular Cancer Research · Jan 3, 2019Peer-reviewedMolecular Biology