Maxime Bourguet

The paper identifies a positive feedback loop between GABARAP and PtdIns3K-C1 that drives PtdIns3P production, essential for autophagosome biogenesis.

The paper identifies a novel RAB5 binding site in human VPS34-CII and suggests it is the primordial site in eukaryotic evolution.

This paper shows that pervanadate induces oxidation, which activates SRC kinases by disrupting autoinhibition and altering SH2 domain phosphopeptide binding, revealing a redox-dependent mechanism for SRC activation.

This study reveals the structural basis of a phosphoinositide-driven mTORC2-AKT positive feedback loop through cryo-EM structures and functional analysis.

This study identifies structural and biophysical details of the MED1-VDR-RXR interaction, revealing new insights into coactivator recognition by nuclear receptor complexes.