Jennifer Zou

Chromatin state modeling across individuals reveals global patterns of histone modifications

The paper uses a stacked chromatin state model to identify global patterns of histone modifications across individuals and applies them to predict transregulators and identify trans-QTL in disease contexts.

Accurate modeling of replication rates in genome-wide association studies by accounting for winner's curse and study-specific heterogeneity

The paper develops a statistical framework to model replication rates in GWAS by accounting for winner's curse and study-specific heterogeneity, showing significant variation in confounding factors across studies.

Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility

The paper combines data from two independent mouse studies to identify genetic loci for traits, finds poor replication rates, and proposes a method to assess confidence in associations.

Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication

This study investigates replication challenges in GWAS using two mouse cohorts, finding limited replication success despite similar sample sizes and population origins.

Leveraging allele-specific expression to refine fine-mapping for eQTL studies

This paper develops a statistical method that uses allele-specific expression and eQTL data to improve fine-mapping of causal variants for gene expression, achieving higher specificity than eQTL-only approaches.