Natalia M. Gonzales

The paper identifies genetic variants associated with cardiotoxic responses to chemotherapeutic drugs using single-cell RNA-seq and eQTL analysis.

This paper develops a guided differentiation protocol to generate cardiac cell aggregates (cardiac HDCs) from iPSCs, enabling the study of cardiac cell diversity through single-cell RNA-sequencing.

The paper genotypes over 4,000 Sprague Dawley rats to characterize genetic diversity and performs GWAS on Pavlovian conditioned approach behavior, identifying 46 significant loci.

The paper develops a statistical test to detect polygenic epistasis by analyzing genotype-by-ancestry interactions in mice and yeast, finding significant associations across multiple phenotypes.

This study investigates replication challenges in GWAS using two mouse cohorts, finding limited replication success despite similar sample sizes and population origins.

This study identifies genetic loci associated with muscle mass in humans and mice, finds shared genetic mechanisms, and identifies CPNE1 and STC2 as modifiers of myogenesis.

The paper uses a mouse advanced intercross line to identify genetic associations and eQTLs for traits related to human health and disease.