Alexander T. Wenzel

This study shows that interferon gamma restores antigen presentation in medulloblastoma and enhances T cell-mediated tumor killing in a mouse model.

This study shows that inactivating HIRA during embryonic development affects melanoblasts and leads to aging-related defects in melanocyte stem cells, but not in postnatal melanocytes.

The paper identifies six molecular subtypes of GIST using single nucleus RNA sequencing and correlates them with clinicopathologic features and clinical outcomes.

This study identifies MICAL2 as a super enhancer-associated gene that promotes pancreatic cancer growth and metastasis through multiple molecular mechanisms.

The paper refines gene expression signatures using multi-omics data to improve enrichment analysis by addressing lack of coordinate expression in gene sets.

The paper evaluates ssGSEA's performance on scRNA-seq data, finds it unreliable due to sparsity, and identifies UCell as more robust for pseudobulk analysis.

NMFClustering provides GPU-accelerated non-negative matrix factorization for efficient clustering of large RNA-Seq and scRNA-seq datasets.

The paper introduces a framework to predict how changes in omics data affect metabolic functions in mammalian cells using curated metabolic tasks and genome-scale networks.