Robert J. Wechsler‐Reya

Medulloblastoma Forms Symbiotic Metabolic Partnerships with Macrophages to Establish Leptomeningeal Metastases

This study identifies metabolic partnerships between medulloblastoma and macrophages that drive leptomeningeal metastases and suggests targeting the CXCL12-SCARB1-cholesterol axis as a therapeutic strategy.

Preservation and Clonal Behavior of Extrachromosomal DNA in Patient-Derived Xenograft Models of Childhood Cancers

This study compares ecDNA prevalence, conservation, and clonal dynamics in PDX models and primary tumors of childhood cancers, finding high sequence conservation and selective growth advantage of ecDNA-positive clones.

Nanoparticle encapsulation enhances spatial distribution of Panobinostat to treat metastatic medulloblastoma via the intrathecal route

This study develops a nanoparticle system to deliver Panobinostat intrathecally for treating metastatic medulloblastoma, showing improved drug distribution and survival benefits in mice.

ONC206 demonstrates potent anti-tumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma

This study shows ONC206 effectively kills medulloblastoma cells and extends survival in mouse models, supporting its potential as a new treatment for high-risk medulloblastoma.

Interferon Restores Antigen Presentation and Sensitizes Medulloblastoma to T Cell Killing

This study shows that interferon gamma restores antigen presentation in medulloblastoma and enhances T cell-mediated tumor killing in a mouse model.

CD155 regulates tumor growth and immune evasion in diffuse midline glioma.

This study identifies CD155 as a key regulator of tumor growth and immune evasion in diffuse midline glioma, showing that targeting CD155 or its downstream target FOXM1 can inhibit tumor progression.

Ras-Responsive Element Binding Protein 1 regulates survival of Group 3 medulloblastoma

This study identifies RREB1 as a key driver of Group 3 medulloblastoma, showing its role in tumor growth and survival through the c-MET signaling pathway.

Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements

This paper identifies how PVT1 rearrangements in MYC+ cancers generate oncogenic peptides that synergistically activate MYC, AKT, and RAS-MAPK pathways, enhancing tumor aggressiveness.

Elucidation and Pharmacologic Targeting of Master Regulator Dependencies in Coexisting Diffuse Midline Glioma Subpopulations

The paper identifies master regulator dependencies in coexisting diffuse midline glioma subpopulations and shows that combination therapy targeting these regulators improves survival in vivo.