Author

Shirom Chabra

Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0002-2061-6326Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Berthold GöttgensiD· 3 shared Melania BarileiD· 2 shared Andrew M. BlagboroughiD· 1 shared Christiana GeorgiouiD· 1 shared Constandina PosporiiD· 1 shared Cristina Lo CelsoiD· 1 shared Elisa LaurentiiD· 1 shared Emily F. CalderbankiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioinformatics

Berthold GöttgensORCID

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3 papers

Recent·Most cited

BioinformaticsBioinformaticsPeer-reviewedMay 21, 2025

diffGEK: Differential Gene Expression Kinetics

Melania Barile, Shirom Chabra, Tomoya Isobe, Berthold Göttgens

diffGEK compares transcriptional kinetics across biological conditions to identify mechanistic differences in gene expression dynamics.

DOI 10.1093/bioinformatics/btaf316

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Cell BiologybioRxivPreprintApr 9, 2025

A subset of Haematopoietic Stem Cells resists Plasmodium infection-induced stress by uncoupling interferon sensing and metabolic activation

Christiana Georgiou, Qi Liu, Sara González Antón…·Cristina Lo Celso

The paper identifies two HSC subsets with distinct responses to Plasmodium infection, showing that BiotinHi HSCs remain functional by maintaining a stemness-associated metabolic profile despite sensing inflammation.

DOI 10.1101/2025.04.09.647965

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BioinformaticsbioRxivPreprintJul 8, 2024

Unveiling Clonal Cell Fate and Differentiation Dynamics: A Hybrid NeuralODE-Gillespie Approach

Mingze Gao, Melania Barile, Shirom Chabra…·Yuanhua Huang

CLADES estimates clone-specific kinetics and fate bias in human cord blood LT-scSeq data using a NeuralODE-Gillespie hybrid approach, improving meta-clone fate prediction accuracy.

1 citation

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