Melania Barile

The paper uses human iPSC-derived 3D trunk-like structures to study mesodermal lineage decisions and identifies TBX6 and FOXC1/2 as key regulators in human trunk mesoderm diversification.

Pseudodynamics+ reconstructs population dynamics from time-resolved single-cell data using physics-informed neural networks, revealing dynamic changes in cell state parameters.

diffGEK compares transcriptional kinetics across biological conditions to identify mechanistic differences in gene expression dynamics.

This study shows MLL2 stabilizes 3D chromatin loops during pluripotent cell differentiation without requiring its enzymatic activity.

CLADES estimates clone-specific kinetics and fate bias in human cord blood LT-scSeq data using a NeuralODE-Gillespie hybrid approach, improving meta-clone fate prediction accuracy.

The paper identifies coordinated step-changes in gene expression kinetics during erythropoiesis in both mouse and human, challenging assumptions of RNA velocity analysis.

The paper investigates HSC division patterns in mice, finding most divisions are symmetric self-renewing, maintaining HSC output despite age-related decline in differentiation.