Author

Maoshen Sun

Center for Life SciencesORCID 0000-0002-8602-4817Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

Huasong AiiD· 2 shared Lei LiuiD· 2 shared Yunxiang DuiD· 2 shared Guo‐Chao ChuiD· 1 shared Jiabin LiiD· 1 shared Kezhang HeiD· 1 shared Lujun LiangiD· 1 shared Man PaniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Huasong AiORCID

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2 papers

Recent·Most cited

Mechanistic Insights into the Stimulation of the Histone H3K9 Methyltransferase Clr4 by Proximal H3K14 Ubiquitination

Yunxiang Du, Maoshen Sun, Zhengqing Li, Xiangwei Wu, Qian Qu, Huasong Ai, Lei Liu

The paper determines the crystal structures of Clr4 bound to ubiquitinated and unmodified H3 peptides, revealing how H3K14 ubiquitination synergistically enhances Clr4 catalytic activity through conformational changes and multivalent interactions.

Science Advances · May 30, 2025Peer-reviewedMolecular Biology

Synovial Sarcoma X Breakpoint 1 Protein uses a cryptic groove to selectively recognize H2AK119Ub Nucleosomes

Zebin Tong, Huasong Ai, Ziyu Xu, Kezhang He, Guo‐Chao Chu, Qiang Shi, Zhiheng Deng, Qiaomei Xue, Maoshen Sun, Yunxiang Du, Lujun Liang, Jiabin Li, Man Pan, Lei Liu

This study identifies a unique mechanism by which SSX1 recognizes H2AK119Ub nucleosomes through a cryptic groove, enabling specific hijacking of the BAF complex in synovial sarcoma.

Nature Structural & Molecular Biology · Jan 4, 2024Peer-reviewedMolecular Biology