Brittany M. Hufft‐Martinez

This study shows that loss of SPECC1L in cranial neural crest cells causes increased Hedgehog signaling and craniofacial defects similar to human syndrome.

The paper shows that SPECC1L regulates F-actin levels, which in turn affects cilia length and palate development, with a genetic interaction with Thm1.

This study reveals the dynamic timing and sex-specific differences in palatal shelf elevation in mouse embryos using high-resolution imaging.

This study identifies Thm2 as a novel locus that interacts with Thm1 and sensitizes to Hedgehog signaling in postnatal skeletal development, leading to osteochondrodysplasia.