Bailey A. Allard

Intraflagellar transport-A deficiency attenuates ADPKD in a renal tubular- and maturation-dependent manner

This study shows that deleting the IFT-A gene Thm1 in ADPKD mouse models has development-specific effects on kidney cysts, inflammation, and cilia length, suggesting environmental factors influence ciliary homeostasis and disease progression.

Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis

This study identifies Thm2 as a novel locus that interacts with Thm1 and sensitizes to Hedgehog signaling in postnatal skeletal development, leading to osteochondrodysplasia.

Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary protein trafficking, Hedgehog signaling and embryogenesis

This study investigates the roles of Thm1 and Thm2 in cilia function and embryogenesis using mouse embryonic fibroblasts, revealing their distinct and overlapping contributions to ciliary dynamics and signaling.