Genetic ablation of neuronal mitochondrial calcium uptake halts Alzheimer's disease progression
Pooja Jadiya, E.V. Berezhnaya, Devin W. Kolmetzky, Dhanendra Tomar, Henry M. Cohen, Shatakshi Shukla, Manfred Thomas, Salman Khaledi, Joanne F. Garbincius, Liam Kennedy, Oniel Salik, Darpan Raghav, Alycia N. Hildebrand, John W. Elrod
This study shows that reducing neuronal mitochondrial calcium uptake in AD mouse models decreases pathology, synaptic dysfunction, and cognitive decline.
The EMBO Journal · May 22, 2026Peer-reviewedNeuroscience