Cell BiologybioRxivPreprint
The COX2-PGE2-PKA Axis Suppresses Antiviral Immunity by Inhibiting mtDNA-Dependent STING Activation.
Pham Thuy Tien Vo, Julien Cicero, Zichen Wang…·Jorge Silvio Gutkind
This study identifies the COX2-PGE2-PKA axis as a negative regulator of mtDNA-STING signaling, which suppresses antiviral immunity by inhibiting STING activation through mitophagy.
DOI 10.64898/2026.04.03.716411