Pham Thuy Tien Vo

The paper identifies SCAF1 as a key mediator of peroxisome-to-mitochondria signaling under import stress, showing its role in suppressing mitoribosome biogenesis and driving cellular senescence.

This study identifies the COX2-PGE2-PKA axis as a negative regulator of mtDNA-STING signaling, which suppresses antiviral immunity by inhibiting STING activation through mitophagy.

This study shows that peroxisome import stress reduces ribosome biogenesis and activates the integrative stress response through eIF2α phosphorylation in both Drosophila and human cells.