Author

Jaecheol Lee

Sungkyunkwan UniversityORCID 0000-0002-2070-7463Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Aleksandar SpasiciD· 1 shared Carlo CondelloiD· 1 shared Davide ProvasiiD· 1 shared Donghoon AhniD· 1 shared Dongmin Gim· 1 shared Han-Joo KimiD· 1 shared Ho‐Keun KwoniD· 1 shared Jun Zhi XuiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Aleksandar SpasicORCID

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2 papers

Recent·Most cited

Targeting glial PD-1/PD-L1 restores microglial homeostasis and attenuates neuronal hyperactivity in Alzheimer's disease model

Taeyoung Park, Leechung Chang, Seung Won Chung, Seowoo Lee, Sungjun Bae, Carlo Condello, Yong Ho Kim, Jaecheol Lee, Han-Joo Kim, Ho‐Keun Kwon, Minah Suh

This study shows that targeting the PD-1/PD-L1 axis in glial cells improves microglial function and reduces neuronal hyperactivity in an Alzheimer's disease mouse model.

Science Advances · Sep 18, 2026Peer-reviewedNeuroscience

Gαs slow conformational transition upon GTP binding and a novel Gαs regulator

Donghoon Ahn, Davide Provasi, Nguyen Minh Duc, Jun Zhi Xu, Leslie A. Salas-Estrada, Aleksandar Spasic, Min Woo Yun, Juyeong Kang, Dongmin Gim, Jaecheol Lee, Yang Du, Marta Filizola, Ka Young Chung

The paper characterizes the conformational changes in the Gαs protein upon GTP binding and identifies a novel regulator, MAGE D2, using a Bayesian integrative modeling approach.

iScience · Apr 8, 2023Peer-reviewedMolecular Biology