Leslie A. Salas-Estrada

This study uses ultrafast X-ray scattering to observe retinal cis-trans isomerization in rhodopsin, revealing how cofactor dynamics drive activation without crystal lattice constraints.

This paper describes the structure and function of M.BceJIV, a DNA methyltransferase in Burkholderia cenocepacia, showing it binds two DNA sequences simultaneously for methylation.

This study uses a generative deep learning framework to design new KOR antagonists, which are prioritized for synthesis and validated through experimental assays.

The paper characterizes the conformational changes in the Gαs protein upon GTP binding and identifies a novel regulator, MAGE D2, using a Bayesian integrative modeling approach.

This study identifies subtype-specific differences in transmembrane domain interactions that influence metabotropic glutamate receptor activation.