Author

Johannes F. Weijman

University of BristolORCID 0000-0002-2082-5777Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:electronic health records· 1

Frequent Co-Authors

Derek N. WoolfsoniD· 2 shared Jessica A. CrossiD· 2 shared Judith MantelliD· 2 shared Mark P. DoddingiD· 2 shared Shivam ShuklaiD· 2 shared Christiane SchaffitzeliD· 1 shared Jonathan J. PhillipsiD· 1 shared Laura O’ReganiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Derek N. WoolfsonORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivApr 8, 2025

Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch

Shivam Shukla, Jessica A. Cross, Monika Kish…·Mark P. Dodding

This study shows that cargo-sensitive TPR switch in kinesin-1 controls its conformational dynamics by dislocating the TPR shoulder, promoting motor domain activation and microtubule binding.

DOI 10.7554/elife.109462.3

electronic health recordsexperimental assay

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Synthetic BiologyNature Chemical BiologyPeer-reviewedJun 7, 2024

Allosteric regulation of a molecular motor through de novo protein design

Jessica A. Cross, William Dawson, Shivam Shukla…·Derek N. Woolfson

The paper engineers an allosteric switch in kinesin-1 motors using de novo peptides, showing increased transport in cells through conformational changes.

21 citationstop 4%

experimental assay

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