Judith Mantell

Distinct roles for TANGO1S domains in maintaining ER-Golgi architecture

This study investigates the functional roles of TANGO1S domains in maintaining ER-Golgi architecture by analyzing domain-deletion mutants in knockout cells.

Cryo-FIB Lift-out and Electron Tomography Workflow for Bacteria-Nanopillar Interface Imaging Under Native Conditions: Investigating Dragonfly Inspired Bactericidal Titanium Surfaces

This paper develops a cryo-FIB lift-out and electron tomography workflow to image bacteria-nanostructure interfaces under native hydrated conditions.

Synaptic high-frequency jumping synchronises vision to high-speed behaviour

The paper shows how houseflies maintain visual accuracy during fast motion by using synaptic high-frequency jumping, which enhances visual bandwidth and reduces delays.

Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch

This study shows that cargo-sensitive TPR switch in kinesin-1 controls its conformational dynamics by dislocating the TPR shoulder, promoting motor domain activation and microtubule binding.

Allosteric regulation of a molecular motor through de novo protein design

The paper engineers an allosteric switch in kinesin-1 motors using de novo peptides, showing increased transport in cells through conformational changes.

Maturation and conformational switching of a de novo designed phase-separating polypeptide

This study describes a de novo designed polypeptide that forms phase-separated droplets and fibers, showing droplet maturation into β-conformations similar to pathological assemblies.

Discovery and biosynthetic assessment of Streptomyces ortus sp nov. isolated from a deep-sea sponge

This paper isolates a new Streptomyces species from a deep-sea sponge and identifies six unique biosynthetic gene clusters through comparative analysis.

De Novo Designed Peptide and Protein Hairpins Self-assemble into Sheets and Nanoparticles.

This paper designs peptides that self-assemble into nanoparticles or sheets based on disulfide bond placement, using computational modeling and microscopy.