Aras N. Mattis

This study shows that TMEM55B loss disrupts lipid metabolism by altering lipophagy and mitochondrial function, worsening MASLD in mice.

This paper develops an iPSC-based risk predictor for MASLD using lipid accumulation measurements and validates it across three cohorts with varying performance.

This study identifies MIR192 as a regulator of GLP-1 receptor expression, showing it improves statin-induced impairment of insulin secretion.

This study shows that targeting acid ceramidase reduces fibrosis in mouse models of NASH without worsening metabolic features.

This study improves iPSC differentiation into endoderm by using doxycycline to enhance survival via AKT phosphorylation, achieving 90% endoderm formation in over 70 iPSC lines.