Author

Mahmud Hossain

Sanofi (United States)ORCID 0000-0002-2102-3389Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:non-human primate· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Bradford M. ElmeriD· 2 shared Christian MuelleriD· 2 shared Dhiman Ghosh· 2 shared Erik Wischhof· 2 shared Jie BuiD· 2 shared Lilu Guo· 2 shared Martin Goulet· 2 shared Shih-Ching Chou· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Bradford M. ElmerORCID

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2 papers

Recent·Most cited

AAV gene therapy for GBA-PD and Gaucher Disease

Swathi Ayloo, Jae Cheon Ryu, Shih-Ching Chou, Lydia Blatnik, Erik Wischhof, Jie Bu, Lilu Guo, Mahmud Hossain, Dhiman Ghosh, William McCarty, Ann Byrne, Lilly Chai, J T Clarke, Can Kayatekin, Bailin Zhang, , Shyam S. Ramachandran

This paper describes an AAV-mediated gene therapy strategy for GBA1-PD and Gaucher Disease, demonstrating robust GCase replenishment and cross-correction in preclinical models.

bioRxiv · Jun 17, 2025 · PreprintNeuroscience

AAV-mediated ARSA replacement for the treatment of Metachromatic Leukodystrophy

Shyam Ramachandran, Jeffery Ardinger, Jie Bu, MiAngela Ramos, Lilu Guo, Dhiman Ghosh, Mahmud Hossain, Shih-Ching Chou, Yao Chen, Erik Wischhof, Swathi Ayloo, Roger Trullo, Yuxia Luo, Jessica M. Hogestyn, Daniel DuBreuil, , Christian Mueller

This study develops an AAV vector for ARSA gene replacement in MLD, showing improved brain biodistribution and therapeutic effects in mice and non-human primates.

bioRxiv · Mar 12, 2025 · PreprintNeuroscience