Alice S. Chen‐Plotkin

Single-Molecule Imaging Reveals Differential Stability of Alpha-Synuclein Aggregates

This study uses single-molecule imaging to show that Parkinson's disease-associated alpha-synuclein aggregates are more stable than physiological multimers under dilution.

Microglial reactivity in the hippocampal CA2 is associated with advanced neuronal α-synucleinopathy

This study examines the association between microglial reactivity and neuronal α-synucleinopathy in specific hippocampal subfields in Lewy body disease patients.

Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer's Disease

This study identifies distinct presynaptic protein networks in Lewy body dementia that differ from Alzheimer's disease using network proteomics.

α-Synuclein Conformations in Plasma Distinguish Parkinson's Disease from Dementia with Lewy Bodies

The paper identifies plasma α-synuclein conformations that distinguish Parkinson's disease from dementia with Lewy bodies and predict cognitive decline in PD.

Assessment of extracellular vesicle protein cargo as neurodegenerative disease biomarkers

This study develops methods to measure proteins inside extracellular vesicles and applies them to assess neurodegenerative disease biomarkers in plasma.

Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid using mass spectrometry-based proteomics

The paper identifies potential biomarkers for progressive supranuclear palsy (PSP) in cerebrospinal fluid using proteomics, finding ATP6AP2 as the top performer in distinguishing PSP from Parkinson's Disease and controls.

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

This study identifies GSDME as a mediator of mitochondrial damage and axon loss in neurodegenerative diseases, showing its role in ALS and FTD models.

TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy

This study investigates how TMEM106B and C9orf72 genetic variants influence TDP-43 pathology in ALS and FTLD-TDP, finding TMEM106B modifies TDP-43 aggregation severity.

L1CAM is not Associated with Extracellular Vesicles in Human Cerebrospinal Fluid or Plasma

The paper shows L1CAM is not associated with extracellular vesicles in human plasma or CSF and provides tools to evaluate other markers for NDEV isolation.

AAV-mediated progranulin delivery to a mouse model of progranulin deficiency causes T cell-mediated hippocampal degeneration

This study shows that AAV-mediated GRN overexpression in mice causes hippocampal degeneration and T cell infiltration, raising safety concerns for GRN-based CNS gene therapies.

A dementia-associated risk variant near TMEM106B alters chromatin architecture and gene expression

The paper identifies a causal variant near TMEM106B that alters chromatin architecture and gene expression, linking it to frontotemporal lobar degeneration and neurodegenerative disease risk.