Stage-Specific Regulation of DNA Damage Repair by the Circadian Regulator, CRY1, in Prostate Cancer
Arwa Fallatah, Stefan DiFazio, Lakshmi Ravindranath, Thomas Janas, Filippo Pederzoli, Laila N. Scroggins, Noor Abdalla, Orly I. Richter, Sally I. Elsamanoudi, Amina Ali, Jiji Jiang, Isabell A. Sesterhenn, Cara C. Schafer, Massimo F. Loda, Gregory Thomas Chesnut, , Ayesha A. Shafi
This study identifies CRY1 as a stage-specific regulator of DNA damage repair in prostate cancer, showing it promotes NHEJ/BER in hormone-sensitive disease and HR in castration-resistant disease.
bioRxiv · May 21, 2026 · PreprintCancer Biology