This study uses proteogenomics to identify ancestry-specific and shared molecular drivers in prostate cancer, revealing distinct biological programs and improving risk prediction.

bioRxiv · Nov 28, 2025 · PreprintCancer Biology

Quantitative Proteomics Identifies Conserved Proteins and Altered Regulation of Mucin-16 in Low Grade Serous Ovarian Cancers

Christopher M. Tarney, Paulette Y. Mhawech-Fauceglia, Jonathan D. Ogata, Julie Oliver, Tamara S. Abulez, Philip A. Branton, Saeid Movahedi‐Lankarani, Brian L. Hood, Kelly A. Conrads, Kendal Frances Rosalik, Kwong‐Kwok Wong, David Marc Gershenson, Sanghoon Lee, Anil K. Sood, Robert C. Bast, , Nicholas W. Bateman

The paper identifies conserved protein alterations and elevated MUC16 in low-grade serous ovarian cancers through quantitative proteomics and validation across multiple datasets.

Clinical Proteomics · Oct 6, 2025Peer-reviewedCancer Biology

ProteoMixture: A Cell Type Deconvolution Tool for Bulk Tissue Proteomics Data

Pang-ning Teng, Joshua P. Schaaf, Tamara S. Abulez, Brian L. Hood, Katlin N. Wilson, Tracy J. Litzi, David Mitchell, Kelly A. Conrads, Allison L. Hunt, Victoria Olowu, Julie Oliver, Fred S. Park, Marshé Edwards, AiChun Chiang, Matthew D. Wilkerson, , Nicholas W. Bateman

ProteoMixture estimates cell type proportions in bulk tissue proteomics data using optimized protein signatures validated on high-grade serous ovarian cancer samples.

iScience · Feb 12, 2024Peer-reviewedBioinformatics

A modified dual preparatory method for improved isolation of nucleic acids from laser microdissected fresh-frozen human cancer tissue specimens

Danielle C. Kimble, Tracy J. Litzi, Gabrielle Snyder, Victoria Olowu, Sakiyah TaQee, Kelly A. Conrads, Jeremy Loffredo, Nicholas W. Bateman, Camille Alba, Elizabeth Rice, Craig D. Shriver, George Larry Maxwell, Clifton L. Dalgard, Thomas P. Conrads

The paper describes a modified dual preparatory method to improve RNA yield from laser microdissected human cancer tissue samples.

Biology Methods and Protocols · Jan 1, 2024Peer-reviewedBiochemistry

Standardization and Harmonization of Distributed Multi-National Proteotype Analysis supporting Precision Medicine Studies

Yue Xuan, Nicholas W. Bateman, Sébastien Gallien, Sandra Götze, Yue Zhou, Pedro Navarro, Mo Hu, Niyati Parikh, Brian L. Hood, Kelly A. Conrads, Christina Looße, Reta Birhanu Kitata, Sander R. Piersma, Davide Chiasserini, Hongwen Zhu, , Thomas P. Conrads

This paper standardizes a proteotype analysis workflow across multiple international sites to enable distributed, reproducible proteomic data generation for precision medicine.

Nature Communications · Oct 16, 2020Peer-reviewedMolecular Biology