Brian L. Hood

ShapeUpLMD: An Automated Pipeline for Spatially Optimized Laser Microdissection in Multi-omic Tissue Profiling

ShapeUpLMD automates ROI optimization for laser microdissection, improving tumor purity and spatial accuracy in multi-omic tissue profiling.

Integrated proteogenomics uncovers ancestry-specific and shared molecular drivers in localized prostate cancer

This study uses proteogenomics to identify ancestry-specific and shared molecular drivers in prostate cancer, revealing distinct biological programs and improving risk prediction.

Quantitative Proteomics Identifies Conserved Proteins and Altered Regulation of Mucin-16 in Low Grade Serous Ovarian Cancers

The paper identifies conserved protein alterations and elevated MUC16 in low-grade serous ovarian cancers through quantitative proteomics and validation across multiple datasets.

ProteoMixture: A Cell Type Deconvolution Tool for Bulk Tissue Proteomics Data

ProteoMixture estimates cell type proportions in bulk tissue proteomics data using optimized protein signatures validated on high-grade serous ovarian cancer samples.

Standardization and Harmonization of Distributed Multi-National Proteotype Analysis supporting Precision Medicine Studies

This paper standardizes a proteotype analysis workflow across multiple international sites to enable distributed, reproducible proteomic data generation for precision medicine.

Cyclin-dependent kinase 2 (Cdk2) controls phosphatase-regulated signaling and function in platelets

This study shows that Cdk2 is required for platelet activation by inhibiting PP1 phosphatase activity and promoting Erk activation through phosphorylation of PPP1R12a.