Cancer BiologybioRxivPreprint
Novel peptide targeting CXCR4 disrupt tumor-stroma crosstalk to eliminate migrating cancer stem cells
Kanishka Tiwary, Anton Lahusen, Syeda Inaas…·Patrick Christian Hermann
This study identifies a CXCL12/CXCR4/BMI1 signaling axis that promotes metastasis in PDAC via tumor-stroma crosstalk and shows that JM#21, a CXCR4 inhibitor, suppresses miCSCs and enhances chemotherapy efficacy.
2 citations