Author
Memorial Sloan Kettering Cancer CenterORCID 0000-0003-0025-3668Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Élodie Roger, Hannah M Mummey, Eleni Zimmer…·Alexander Kleger
This study shows that ATM-deficient pancreatic cancers reprogram the tumor microenvironment via TGF-β-driven myCAF enrichment, and targeting this stromal axis with chemotherapy improves therapeutic efficacy.
Kanishka Tiwary, Anton Lahusen, Syeda Inaas…·Patrick Christian Hermann
This study identifies a CXCL12/CXCR4/BMI1 signaling axis that promotes metastasis in PDAC via tumor-stroma crosstalk and shows that JM#21, a CXCR4 inhibitor, suppresses miCSCs and enhances chemotherapy efficacy.
Maria Kathrina Oñate, Chet Huan Oon, Sohinee Bhattacharyya…·Mara H. Sherman
The paper identifies loss of stromal KITL as a mechanism promoting tumor progression in the pancreas by disrupting tissue homeostasis.