Splenic MARCO+ marginal zone macrophages regulate rapid production of MCP-1 and KC but are dispensable for alloantibody generation in response to stored RBCs in a murine model.
Abhinav Arneja, Juan E. Salazar, Jelena Medved, Sarah J. Ratcliffe, Mark E. Smolkin, Manjula Santhanakrishnan, Sean R. Stowell, Krystalyn E. Hudson, James C. Zimring, Jeanne E. Hendrickson, Chance John Luckey
This study shows splenic MARCO+ marginal zone macrophages (MZMs) enhance cytokine production but are not required for anti-RBC alloantibody generation after stored RBC transfusion in mice.
bioRxiv · Feb 11, 2025 · PreprintImmunology