Lin Huang

The paper determines the structure and catalytic mechanism of two new HDV ribozymes from a nematode and a virus, revealing a unique Lewis acid mechanism distinct from other ribozymes.

FlexRibbon is a pretrained protein model that jointly learns from sequences and structures, achieving state-of-the-art performance in mutation-rich settings.

This study shows that METTL14 is essential for mouse post-implantation development by promoting epiblast maturation from naive to primed state.