Jingyu Chen

PASTRI infers stage-specific cell-state transition rates from annotated cell lineages, revealing rate-limiting steps and attractor states in development and disease.

This study identifies tissue-resident lymphocytes as drivers of age-associated emphysema by impairing alveolar regeneration and shows IL-7R inhibition can reverse lung damage.

The paper examines dynamic connectome lateralization in autism across childhood, finding developmental changes and associations with clinical and transcriptomic features.

The paper uses single-cell transcriptomes and lineage trees to show that sub-CLTs are stereotyped across biological replicates, indicating a robust developmental program.