Peter Gockel

Expanding the iModulon Knowledgebase for Bacillus subtilis: Updated Transcriptome Decomposition Reveals Novel Regulatory Mechanisms

The paper updates the iModulon decomposition of Bacillus subtilis transcriptomes using 782 RNAseq samples, revealing 142 iModulons that capture 80% of expression variance and provide new insights into gene regulation.

CASCADE-Cas3 Enables Highly Efficient Genome Engineering in Streptomyces Species

The paper introduces a type I-C CRISPR system, pCRISPR-Cas3, for efficient genome engineering in streptomycetes, outperforming Cas9-based systems in deletion and substitution capabilities.

Machine Learning Uncovers the Transcriptional Regulatory Network for the Production Host Streptomyces albidoflavus

The paper uses independent component analysis to characterize the transcriptional regulatory network of Streptomyces albidoflavus and identifies iModulons that describe its activity across growth conditions.