Author

Renata Sigrist

Novo Nordisk FoundationORCID 0000-0002-9342-7470Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Peter GockeliD· 2 shared Tetiana GreniD· 2 shared Anna Svetlova· 1 shared Bernhard Ørn PalssoniD· 1 shared Christopher M. WhitfordiD· 1 shared David FaurdaliD· 1 shared Emre ÖzdemiriD· 1 shared Lei YangiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSynthetic Biology

Peter GockelORCID

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2 papers

Recent·Most cited

CASCADE-Cas3 Enables Highly Efficient Genome Engineering in Streptomyces Species

Christopher M. Whitford, Peter Gockel, David Faurdal, Tetiana Gren, Renata Sigrist, Tilmann Weber

The paper introduces a type I-C CRISPR system, pCRISPR-Cas3, for efficient genome engineering in streptomycetes, outperforming Cas9-based systems in deletion and substitution capabilities.

Nucleic Acids Research · Mar 20, 2025Peer-reviewedSynthetic Biology

Machine Learning Uncovers the Transcriptional Regulatory Network for the Production Host Streptomyces albidoflavus

Mathias Jönsson, Renata Sigrist, Tetiana Gren, Mykhaylo Semenov Petrov, Nils Emil Junge Marcussen, Anna Svetlova, Pep Charusanti, Peter Gockel, Bernhard Ørn Palsson, Lei Yang, Emre Özdemir

The paper uses independent component analysis to characterize the transcriptional regulatory network of Streptomyces albidoflavus and identifies iModulons that describe its activity across growth conditions.

bioRxiv · Jan 9, 2024 · PreprintGenomics