Pep Charusanti

This study analyzes 1432 transcriptomics datasets from 132 Actinomycetota strains to identify patterns of BGC expression and regulatory mechanisms.

RetroMol converts natural product structures and biosynthetic gene clusters into shared primary sequences to enable biosynthetic similarity comparisons.

This paper introduces a method using protein language models to construct pangenomes, achieving better cluster quality and functional consistency than existing tools.

The paper provides over 1,000 high-quality Actinomycetia genomes, revealing genomic structures and biosynthetic gene cluster organization with ecological and biotechnological implications.

The paper reports the discovery of maramycin, a novel isoquinolinequinone alkaloid produced through heterologous expression of a bifunctional enzyme in Streptomyces albidoflavus, showing moderate cytotoxicity against prostate cancer cells.

The paper analyzes 2,371 Streptomyces genomes to refine biosynthetic gene cluster (BGC) diversity using MASH-clusters and reveals conserved genomic structures suggesting vertical inheritance.

The paper uses independent component analysis to characterize the transcriptional regulatory network of Streptomyces albidoflavus and identifies iModulons that describe its activity across growth conditions.