Lei Yang

MillionFull enables massive, full-length enzyme sequence-fitness data collection at low cost for machine learning-guided enzyme engineering

MillionFull collects large-scale sequence-fitness data for enzymes at low cost, enabling machine learning for enzyme engineering.

Expanding the iModulon Knowledgebase for Bacillus subtilis: Updated Transcriptome Decomposition Reveals Novel Regulatory Mechanisms

The paper updates the iModulon decomposition of Bacillus subtilis transcriptomes using 782 RNAseq samples, revealing 142 iModulons that capture 80% of expression variance and provide new insights into gene regulation.

Genetic memory devices to detect specialized metabolites in plant and soil microbiomes

The paper develops genetic memory biosensors in E. coli and Pseudomonas putida to detect specialized metabolites in plant and soil microbiomes, enabling non-disruptive, real-time chemical signaling analysis.

Machine Learning Uncovers the Transcriptional Regulatory Network for the Production Host Streptomyces albidoflavus

The paper uses independent component analysis to characterize the transcriptional regulatory network of Streptomyces albidoflavus and identifies iModulons that describe its activity across growth conditions.

Understanding and exploitation of host stress responses to protein production using novel transcriptomic analytics

This study identifies novel transcriptional responses to protein production stress in E. coli using transcriptomic analytics and applies findings to optimize protein production.