Estrogen receptor alpha mediated repression of PRICKLE1 destabilizes REST and promotes uterine fibroid pathogenesis
Michelle M. McWilliams, Faezeh Koohestani, Wendy N. Jefferson, Sumedha Gunewardena, Kavya Shivashankar, Riley A. Wertenberger, Carmen J. Williams, T. Rajendra Kumar, Vargheese M. Chennathukuzhi
This study identifies a mechanism by which estrogen receptor alpha suppresses PRICKLE1, leading to REST loss and promoting uterine fibroid development.
bioRxiv · Sep 9, 2024 · PreprintCell Biology