Wendy N. Jefferson

Neonatal diethylstilbestrol exposure disrupts uterine epithelial apical-basal polarity and partial EMT state

This study investigates how neonatal exposure to diethylstilbestrol disrupts uterine epithelial polarity and partial EMT state in mice, leading to long-term functional impairments and cancer risk.

Estrogen receptor alpha mediated repression of PRICKLE1 destabilizes REST and promotes uterine fibroid pathogenesis

This study identifies a mechanism by which estrogen receptor alpha suppresses PRICKLE1, leading to REST loss and promoting uterine fibroid development.

Endocrine disruption of early uterine differentiation causes adenocarcinoma mediated by Wnt/β-catenin- and PI3K/AKT signaling

The paper investigates how developmental exposure to diethylstilbestrol (DES) disrupts uterine differentiation and leads to adenocarcinoma through Wnt/β-catenin and PI3K/AKT signaling.