ClearFinder provides a Python GUI for cell annotation in cleared mouse brains, improving accessibility and enabling statistical analysis and visualization.

BMC Bioinformatics · Jan 21, 2025Peer-reviewedBioinformatics

Freezing responses during prolonged threat memory retrieval reflect trait-like anxiety endophenotypes in female and male inbred mice

Irina Kovlyagina, Anna Wierczeiko, Hristo Todorov, Eric Jacobi, Margaryta Tevosian, Jakob von Engelhardt, Susanne Gerber, Beat Lutz

The paper identifies sustained freezing during prolonged threat memory retrieval as an anxiety-endophenotype biomarker in both male and female inbred mice, with sex-specific transcriptomic differences in brain regions associated with psychiatric disorders.

PLoS Biology · May 28, 2024Peer-reviewedNeuroscience

Repair oligodendrocytes demyelinating and disintegrating damaged axons after injury

Gianluigi Nocera, Adrien M. Vaquie, Nadège Hertzog, Katharina Steil, Santiago Luis Cañón Duque, Johannes Miedema, Cansu Bagin, Margaryta Tevosian, Beat Lutz, Azadeh Sharifi-Aghili, Katharina Hegner, Doris Vollmer, Seokyoung Bang, Byungjun Lee, Noo Li Jeon, , Claire Jacob

This study identifies Dusp6 as a key inhibitor of oligodendrocyte plasticity after spinal cord injury and shows that its inactivation promotes axonal regrowth by converting oligodendrocytes into repair cells.

bioRxiv · May 18, 2023 · PreprintNeuroscience