Jakob von Engelhardt

This study shows that CLN3 is essential for synaptic function in Batten disease and that early gene therapy can reverse synaptic deficits.

The paper investigates how synaptic strength and short-term plasticity interact at retinogeniculate synapses in mice, finding an inverse relationship where strong synapses depress and weak ones facilitate.

This study identifies functional groups of serotonergic axons in S1 and shows their activity is driven by reward, sensory stimulation, and precedes movement.

The paper identifies sustained freezing during prolonged threat memory retrieval as an anxiety-endophenotype biomarker in both male and female inbred mice, with sex-specific transcriptomic differences in brain regions associated with psychiatric disorders.

This study shows that AMPA receptor desensitization in dLGN relay cells reduces input and response gain and sharpens temporal responses to visual stimuli in vivo.

This study shows maternal inflammation impairs specific stages and subtypes of cortical GABAergic interneuron development, leading to structural and functional changes in the offspring's brain.