A20's Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis
Christopher Bowman, Dorothea Stibor, Xiaofei Sun, Hiromichi Shimizu, Emily Yamashita, Nika Lenci, Rommel Advincula, Min Cheol Kim, Jessie A. Turnbaugh, Yang Sun, Bahram Razani, Peter James Turnbaugh, Chun Ye, Barbara A. Malynn, Averil I. Ma
This study shows that A20's M1 ubiquitin binding motif suppresses TH17/22 cell activation and IL-22-driven enteritis by regulating RORγt and epigenetic changes in T cells.
Journal of Clinical Investigation · Sep 2, 2025Peer-reviewedImmunology