Author

Nika Lenci

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:large language model· 1 Organism:mouse· 1

Frequent Co-Authors

Averil I. MaiD· 2 shared Barbara A. MalynniD· 2 shared Christopher BowmaniD· 2 shared Chun YeiD· 2 shared Dorothea StiboriD· 2 shared Emily Yamashita· 2 shared Rommel Advincula· 2 shared Adam BlaisdelliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Averil I. MaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy

Adam Blaisdell, Stefanie Bachl, Luis R Sandoval, Carter Ching, Christopher Bowman, Nupura Kale, Manu Prabandham, Morgan E. Diolaiti, Claire C. Havig, Rommel Advincula, Nika Lenci, Zhongmei Li, Emily Yamashita, Charlotte H. Wang, Shimin Zhang, , Averil I. Ma

This study uses base-editing to inactivate a missense mutation in A20ZF7, enhancing CAR-T cell efficacy by reducing exhaustion and improving anti-tumor responses.

bioRxiv · Oct 5, 2025 · PreprintImmunology

A20's Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis

Christopher Bowman, Dorothea Stibor, Xiaofei Sun, Hiromichi Shimizu, Emily Yamashita, Nika Lenci, Rommel Advincula, Min Cheol Kim, Jessie A. Turnbaugh, Yang Sun, Bahram Razani, Peter James Turnbaugh, Chun Ye, Barbara A. Malynn, Averil I. Ma

This study shows that A20's M1 ubiquitin binding motif suppresses TH17/22 cell activation and IL-22-driven enteritis by regulating RORγt and epigenetic changes in T cells.

Journal of Clinical Investigation · Sep 2, 2025Peer-reviewedImmunology