Author

Carl Pelz

Oregon Health & Science UniversityORCID 0000-0002-2235-880XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Rosalie C. SearsiD· 5 shared Jennifer R. EngiD· 4 shared Colin J. DanieliD· 3 shared Jonathan Robert BrodyiD· 3 shared Kevin HawthorneiD· 3 shared Motoyuki TsudaiD· 3 shared Patrick Joseph WorthiD· 3 shared Alexander SmithiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

Rosalie C. SearsORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 29, 2026

Epigenetic progression of pancreatic cancer to aggressive subtypes involves alternate routes of lineage reprogramming in subtype-intermediate progenitor cells

Kevin Hawthorne, Jennifer R. Eng, Motoyuki Tsuda…·Rosalie C. Sears

The paper identifies subtype-intermediate progenitor cells in pancreatic cancer with distinct epigenetic profiles linked to clinical outcomes and lineage reprogramming.

DOI 10.64898/2026.09.28.754674

humanscATAC-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 29, 2026

Spatially Resolved Epithelial States Delineate Immunosuppressive Niches of Impaired Myeloid Antigen Presentation in PDAC

Cameron R. Walker, Ruohan Wang, Hadeesha Piyadasa…·Michael Angelo

The paper identifies spatially distinct epithelial states in PDAC that correlate with immunosuppressive myeloid niches and poor prognosis.

DOI 10.64898/2026.07.28.741300

humanspatial transcriptomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 15, 2025

A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway

Motoyuki Tsuda, Dove J. Keith, Colin J. Daniel…·Rosalie C. Sears

The paper identifies resistance mechanisms to KRAS-MEK pathway targeting in PDAC by analyzing clinical trial data and multi-omics profiles, showing that KRAS/MYC co-gain correlates with resistance and that co-targeting these genes is synergistic.

DOI 10.64898/2025.12.12.693851

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 14, 2025

Myc and Kras cooperate in adult acinar cells to drive phenotypic heterogeneity, metastasis, and therapeutic resistance in a novel pancreatic cancer mouse model

Isabel A. English, Patrick Joseph Worth, Kevin Hawthorne…·Rosalie C. Sears

This study develops a novel pancreatic cancer mouse model by expressing Myc and mutant Kras in adult acinar cells, showing metastasis and therapeutic resistance similar to human PDAc.

5 citations

mouseexperimental assay

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMar 19, 2025

MYC Serine 62 phosphorylation promotes its binding to DNA double strand breaks to facilitate repair and cell survival under genotoxic stress.

Gabriel M. Cohn, Colin J. Daniel, Jennifer R. Eng…·Rosalie C. Sears

1 citation

humanDNA methylation

𝕏 PostBluesky