Author

Isabel A. English

Oregon Health & Science UniversityORCID 0000-0002-0566-9585Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Carl PelziD· 2 shared Jennifer R. EngiD· 2 shared Jonathan Robert BrodyiD· 2 shared Katie E. BliseiD· 2 shared Lisa M. CoussensiD· 2 shared Motoyuki TsudaiD· 2 shared Patrick Joseph WorthiD· 2 shared Rosalie C. SearsiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Carl PelzORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 15, 2025

A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway

Motoyuki Tsuda, Dove J. Keith, Colin J. Daniel…·Rosalie C. Sears

The paper identifies resistance mechanisms to KRAS-MEK pathway targeting in PDAC by analyzing clinical trial data and multi-omics profiles, showing that KRAS/MYC co-gain correlates with resistance and that co-targeting these genes is synergistic.

DOI 10.64898/2025.12.12.693851

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintJul 14, 2025

Myc and Kras cooperate in adult acinar cells to drive phenotypic heterogeneity, metastasis, and therapeutic resistance in a novel pancreatic cancer mouse model

Isabel A. English, Patrick Joseph Worth, Kevin Hawthorne…·Rosalie C. Sears

This study develops a novel pancreatic cancer mouse model by expressing Myc and mutant Kras in adult acinar cells, showing metastasis and therapeutic resistance similar to human PDAc.

5 citations

mouseexperimental assay

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